Biocatalysis lab


18. Monomeric Dihydroanthaquinones: A Chemoenzymatic Approach and its (Bio)synthetic Implications for Bisnathraquinones

N. Saha+, A. Mondal+, K. Witte, S. K. Singh, M. Müller, S. M. Husain*  Chemistry: A European Journal 2017, Just Accepted, DOI: 10.1002/chem.201705998 +equal contribution

Graphical Material

17. Fungal Dihydroxynaphthalene-Melanin: Diversity-Oriented Biosynthesis through Enzymatic and Nonenzymatic Transformations

S. M. Husain, M. Müller*  Synlett 2017, 28, 2360-2372.


16. Phylogenetic Studies, Gene Cluster Analysis, and Enzymatic Reaction Support Anthrahydroquinone Reduction as the Physiological Function of Fungal 17beta-Hydroxysteroid Dehydrogenase 

L. Fürtges, D. Conradt, M. A. Schaetzle, S. K. Singh, N. Kraševec, T. L. Rižner, M. Müller,* S. M. HusainChem. Bio. Chem. 2016, 18, 77-80.


15. A quinone mediator drives oxidations catalysed by alcohol dehydrogenase-containing cell lysates
J. Haas, M. A. Schätzle, S. M. Husain, J. Schulz-Fincke, M. Jung, W. Hummel, M. Müller, S. Lüdeke Chem. Comm. 2016, 52, 5198-5201.


14. Tetrahydroxynaphthalene Reductase – Catalytic Properties of an Enzyme Involved in Reductive Asymmetric Naphthol Dearomatization
M. A. Schätzle, S.M. Husain, M. Müller Book Chapter in Practical Methods for Biocatalysis and Biotransformations-3- 2016 Edited by Whitall, Sutton, and Kroutil


13. Diversity in Reduction with Short-Chain Dehydrogenases: Tetrahydroxynaphthalene Reductase, Trihydroxynaphthalene Reductase, and Glucose Dehydrogenase
D. Conradt, M. A. Schätzle, S.M. Husain, M. Müller Chem. Cat. Chem. 2015 [PDF]


12. Unprecedented Role of Hydronaphthoquinone Tautomers in Biosynthesis
S.M. Husain, M. A. Schätzle, S. Lüdeke, M. Müller Angew. Chem. Int. Ed. 201453, 9806-9811.
[PDF] [Supporting info]



From Postdoc

11. Tautomers of Anthrahydroquinones: Enzymatic Reduction and Implications for Chrysophanol, Monodictyphenone, and Related Xanthone Biosyntheses
M. A. Schätzle, S. M. Husain, S. Ferlaino, M. Müller  J. Am. Chem. Soc. 2012, 134, 14742-14745.
[PDF] [Supporting info]

chrysophanol biosynthesis_1

10. Biomimetic Asymmetric Synthesis of (R)-GTRI-02 and (3S,4R)-3,4-Dihydroxy-3,4-dihydronaphthalene-1(2H)-ones  
S. M. Husain, M. A. Schätzle, C. Röhr, S. Lüdeke, M. Müller “” Org. Lett. 2012, 14, 3600-3603.
[PDF] [Supporting info]

9. Stereoselective synthesis of bulky 1,2-diols with alcohol dehydrogenases
J. Kulig, R. C. Simon, C. A. Rose, S. M. Husain, M. Häckh, S. Lüdeke, K. Zeitler, W. Kroutil, M. Pohl, D. Rother Catal. Sci. Technol. 2012, 2, 1580-1589.
[PDF] [Supporting info]

8. Microwave assisted synthesis of 3-benzazepin-2-ones as building blocks for 2,3-disubstituted tetrahydro-3-benzazepines
S. Sarkar, S. M. Husain, D. Schepmann, R. Fröhlich, B. Wünsch “”, Tetrahedron 2012, 68, 2687-2695.

7. Tetrahydroxynaphthalene Reductase – Catalytic Properties of an Enzyme involved in Reductive Asymmetric Naphthol Dearomatization
M. A. Schätzle, S. Flemming, S.M. Husain, M. Richter, S. Günther, M. Müller  Angew. Chem. Int. Ed. 2012, 51, 2643-2646.
[PDF] [Supporting info]

6. Stereoselective reduction of 2-hydroxy ketones towards syn– and anti-1,2-Diols 
S. M. Husain,T. Stillger, P. Dünkelmann, M. Lödige, L. Walter, E. Breitling, M. Pohl, M. Bürchner,I. Krossing, M. Müller, D. Romano,F. Molinari  Adv. Synth. Catal. 2011, 353, 2359-2362.
[PDF] [Supporting info]

From Ph.D.

5. Enantioselective Synthesis of a 2,2-Disubstituted Tetrahydro-3-benzazepine as Novel Receptor Antagonist
S. M. Husain, R. Fröhlich, D. Schepmann, B. Wünsch,  Z. Naturforsch. 2010, 65b, 191-196.
2,2-disubstituted 3-benz plus binding

4. Asymmetric Synthesis and σ receptor affinity of enantiomerically pure 1,4-disubstituted-tetrahydro-1H-3-benzazepines
S. M. Husain, M. T. Heim, D. Schepmann, B, Wünsch,  Tetrahedron: Asymmetry, 2009, 20, 1383-1392.
1,4-disubstituted 2-benz_another_new

3. Asymmetric Synthesis of Enantiomerically pure 2-Substituted-3-benzazepines and Their Affinity to σ1 Receptors
S.M. Husain, R. Fröhlich, D. Schepmann, B. Wünsch, J. Org. Chem. 2009, 74, 2788-2793.
[PDF] [Supporting Info]
2-substituted 3-benz

2. A very short asymmetric synthesis of enantiomerically pure methyl substituted tetrahydro-3-benzazepines 
S. M. Husain, R. Fröhlich, B. Wünsch, Tetrahedron: Asymmetry, 2008, 19, 1613-1616.

1. Synthesis of Phenylacetic Acids with 2-Oxoalkyl Substituents in ortho-Position from o-Phenylenediacetic Acid
S. M. Husain, B. Wünsch, Synthesis, 2008, 17, 2729-2732.